RNA

Part:BBa_K2534003:Design

Designed by: Mohammad Tarek Mansour   Group: iGEM18_AFCM-Egypt   (2018-09-24)


miRNA 134 5p


miRNA-134 5p has been discovered to function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] worked to do lentiviral transfection of that part into colorectal cancer cell line RKO to induce regulatory apoptosis as well as to investigate it's immune modulatory effect on TLR-9. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] have characterized this part considering it's apoptotic effect of RKO cell lines.

For further information about demonstration of its apoptotic effect, please visit our results page http://2018.igem.org/Team:AFCM-Egypt/Demonstrate


Chmir134afcm.png

This parts has been structurally modeled for more information, please visit our modeling page http://2018.igem.org/Team:AFCM-Egypt/Model


T--AFCM-Egypt--2nd_pic.png



Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

This part has been synthesized through IDT offer


Source

http://2018.igem.org/Team:AFCM-Egypt/Bioinformatics_Page_link